Andreas Roos (PhD)
Translational Research in Neuromuscular Disorders

Scientific Career


Since Nov 2015

Permanent position as Scientific Officer at the John Walton Muscular Dystrophy Research Centre (JWMDRC) at the Institute of Genetic Medicine; Newcastle University
Principal Investigators:
Prof. Dr. Kate Bushby, Prof. Dr. Rita Horvath, Prof. Dr. Hanns Lochmüller, Prof. Dr. Volker Straub

Research work area:

  • development and application of strategies for the discovery of the etiology of neuromuscular and neurodegenerative disorders
  • biomarker discovery towards patient-classification
  • identification and testing of modifier proteins of neuromuscular and neurodegenerative disorders
  • testing of therapeutic strategies in the treatment of patients suffering from neuromuscular disorders

Further work areas:

  • supervision of Postdoc, Master and PhD students
  • mass spectrometric studies towards translational medicine
  • represent the JWMDRC on strategy meetings and conferences


2014 – 2015

Non-permanent leader position (“Tissue OMICS”) at the Bioanalytics department of the Leibniz-Institute of Analytical Sciences –ISAS– e.V., Dortmund 
Head: Prof. Dr. rer. nat. A. Sickmann

Research work area:

  • development and application of proteomic strategies for the discovery of the etiology of neuromuscular and neurodegenerative disorders
  • biomarker discovery towards patient-classificationidentification and testing of modifier proteins of neuromuscular and neurodegenerative disorders
  • proteomics strategies towards the evaluation of ambiguous missense variants identified by next generation sequencing 
  • identification of protein-protein interactions via affinity purification and mass spectrometry 

Further work areas:

  • supervision of Postdoc, Master and PhD students
  • developing molecular biological strategies and stable cell lines supporting mass spectrometric studies
  • method optimization for protein extraction out of skeletal and cardiac muscle
  • represent the institute on strategy meetings, conferences and in the “Landtag” (federal state parliament of North Rhine-Westphalia, Germany)


2010 – 2014

Project leader position, Institute of Neuropathology; RWTH Aachen University Hospital
Head: Prof. Dr. med. J. Weis

Research work area: 

  • Study the role of protein quality control and proteolysis in the etiology of neuromuscular and neurodegenerative disorders
  • Young Scientist grant “START” of RWTH Aachen University Hospital
  • Grant of Else Kröner-Fresenius-Stiftung (EKFS): Etiology of Marinesco-Sjögren syndrome (MSS) endophenotypes


Leader of the Molecular Diagnostic laboratory of the Institute of Neuropathology; 
RWTH Aachen University Hospital
Head: Prof. Dr. med. J. Weis

Work area: 

  • supervision and troubleshooting in genetic testing (PCR and sequencing) of patients suffering from neuropathies/ myopathies with clinical genotype-phenotype-correlations
  • evaluation of somatic mutations and promotor methylation in glioblastoma and astrocytoma
  • evaluation of diagnostic immunoblots in diagnostic management of myopathic patients

Further work areas: 

  • teaching of students
  • supervision of Master, MD and PhD students
  • S1 biosafety inspector


2009 – 2010

Postdoctoral Fellow, Institute of Medical Biochemistry; University of Saarland, Homburg
Head: Prof. Dr. rer. nat. R. Zimmermann

Research work area: 

  • Biochemistry of the Endoplasmic Reticulum


2009

Doctoral Examination (Dr. rer. nat./ PhD) “magna cum laude”

 

2005 – 2009

Doctoral candidate, Institute of Human Genetics, RWTH Aachen University Hospital
Head: Prof. Dr. med. K.P. Zerres; 
Supervision: Prof. Dr. med. Jan Senderek
Postgraduate scholarship of RWTH Aachen University 

Research work area: 

  • Molecular genetic and biochemical studies of recessive CMT-neuropathies

Further work areas: 

  • supervision of Master and MD students
  • fire safety inspector
  • Clinical and experimental Molecular Genetics
  • Clinical Genetics


2002 – 2004

Student research assistant, Institute of Human Genetics, RWTH Aachen University Hospital
Head: Prof. Dr. med. K.P. Zerres,
Supervision: Dr. rer. nat. Herdit Schüler

Work area:

  • Clinical and experimental Cytogenetics


    1999 – 2005

    Studies of Biology at RWTH Aachen University

    Main focus on Molecular Medicine: 

    • Human Genetics
    • Molecular Genetics
    • Bacterial and Viral Genetics
    • Molecular Pathology
    • Microbiology

    Graduation with Honors 1,0 (“Springorum-Denkmünze of RWTH Aachen University”)